Creatine, longevity and the central nervous system
Plausible mechanisms, human evidence, and the limits of translation.
What the evidence supports
Creatine has a well-established role in cellular energy buffering. Its strongest practical relevance to healthy aging is as an adjunct to resistance training. Some cognitive and mood effects are promising, especially under energetic stress; human lifespan extension and dementia prevention remain unproven.
Read the report
25 source records. The report distinguishes mechanisms, animal findings, observational evidence, and controlled human trials. Includes diagrams, study limitations, dose and safety context, and linked references.
Evidence and editable sources
Evidence table (CSV) · Editable report sources (ZIP)
Original scholarly reference titles are retained. This focused narrative review is for research and education, not individual medical advice.