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IMF-084-03-0001-en	Why are spermatogonia basal and spermatids near the lumen of a seminiferous tubule?	The layered sequence reflects germ cells moving from basement membrane toward lumen as they pass through mitosis, meiosis, and differentiation.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0002-en	How do Sertoli cells create the blood–testis barrier?	Tight junctions between adjacent Sertoli cells divide the germinal epithelium into basal and adluminal compartments.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0003-en	What distinguishes efferent ductules from the epididymal duct?	Efferent ductules alternate tall ciliated and low absorptive cells, giving a scalloped lumen; the epididymal duct has pseudostratified columnar epithelium with long stereocilia and matures and stores sperm.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0004-en	What determines whether the corpus luteum persists or regresses?	It forms from luteinised granulosa and theca cells and depends on sustained gonadotropin support; without it, it regresses into a fibrous corpus albicans.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0005-en	How do proliferative and secretory endometrium differ, and which hormone drives each?	Under oestrogen, glands are relatively straight and mitotic; under progesterone they show subnuclear vacuoles and tortuosity, with stromal oedema and predecidual change.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0006-en	Why is the junction between endocervix and ectocervix clinically important?	Here mucus-secreting columnar epithelium meets non-keratinised stratified squamous epithelium; the junction shifts with age and hormonal state and is vulnerable to oncogenic human papillomavirus.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0007-en	Why must breast histology be interpreted with reproductive context?	The inactive gland is mainly ducts in stroma, pregnancy produces lobuloalveolar proliferation, and after weaning many secretory units involute.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0008-en	How does melanin protect keratinocytes, and what mainly explains differences in skin colour?	Melanocytes transfer melanin to keratinocytes, where it shields nuclei from ultraviolet radiation; colour differences reflect melanosome production, distribution, and degradation rather than melanocyte number.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0009-en	How does the thick skin of palms and soles differ from thin skin?	Thick skin has a thick epidermis with a stratum lucidum and sweat glands but no hair or sebaceous glands; thin skin has hair follicles, sebaceous glands, arrector pili, and eccrine glands.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0010-en	Why does substantial loss of corneal endothelial cells cause opacity?	Corneal transparency depends on controlled stromal hydration, and the endothelium pumps fluid out of the stroma, so its loss causes oedema and opacity.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0011-en	How do the fovea and the optic disc differ in their contribution to vision?	At the fovea the inner layers are displaced to maximise cone resolution, whereas the optic disc lacks photoreceptors.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0012-en	How do inner and outer hair cells divide the work of hearing?	Inner hair cells provide most auditory transduction, while outer hair cells actively amplify and sharpen vibration.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0013-en	How does splenic red pulp remove damaged erythrocytes?	Flexible erythrocytes cross slits between stave-like sinus endothelial cells to re-enter the circulation, while rigid or damaged cells are retained and removed by macrophages.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending
IMF-084-03-0014-en	What features distinguish the thymus from a lymph node?	The thymus is supported by epithelial reticular cells rather than reticular fibres, has Hassall corpuscles in the medulla, and lacks follicles and afferent lymphatics.	Integrated Medical Foundations; chapter 84, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 89e8da9880c9021603bbd5f226ad1d8f262455b466a09b1903e03297b14e3255; editorial review pending	imf lang::en chapter::084 module::084-03 review::pending