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IMF-069-03-0001-en	Why should care recommendations not be imported merely because the gene name matches?	A different variant mechanism or phenotype in the same gene can mean a different disease, so its recommendations may not apply.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0002-en	Why can the response to treatment of a genetic disorder depend on disease stage?	Correcting the molecular defect cannot always reverse tissue injury that is already established.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0003-en	Why are long-term registries essential for gene-based therapies?	Pivotal trials may have few participants and short follow-up, while risks such as insertional effects, limited durability and uncertain germline exposure emerge over time.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0004-en	When is surveillance justified, and why is more testing not automatically safer?	When risk is meaningfully raised, a test detects a treatable stage and intervention improves outcome; false positives, radiation, sedation, procedures and anxiety accumulate.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0005-en	Once a familial pathogenic variant is known, why is cascade testing preferred to repeating broad sequencing in relatives?	Targeted testing for the known variant clarifies each relative's risk more efficiently.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0006-en	What determines whether testing a minor is favoured or deferred?	Testing is favoured when childhood surveillance or treatment changes outcome, and deferred when benefit begins only in adulthood.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0007-en	Under what conditions might disclosure to a relative without consent be justified?	Rarely, when a serious, likely, preventable harm to an identifiable relative cannot otherwise be addressed, with legal and ethical review, proportionality and minimum disclosure.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0008-en	What does non-directive reproductive counselling mean, and what does it not mean?	It means accurate information and support for choices without implying disability lessens a life's value or that one choice is required; it does not mean withholding professional guidance.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0009-en	Why may confirmatory prenatal testing be offered after preimplantation genetic testing?	Embryo mosaicism and laboratory error complicate interpretation, and the test uses a familial assay that does not examine every possible disorder.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0010-en	Why should race or ethnicity not substitute for pharmacogenomic testing when an actionable genotype is required?	It is only a crude proxy; the individual genotype, translated into an interpretable phenotype, is what guides avoidance or dose adjustment.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0011-en	What two errors limit liquid biopsy for circulating tumour DNA?	It may be falsely negative when tumour shedding is low, and it can detect age-related clonal haematopoiesis unrelated to the tumour.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0012-en	Why can a direct-to-consumer genetic result mislead in both directions?	Examining only selected variants can falsely reassure people with family risk, while apparent pathogenic findings may be false positives needing clinical confirmation.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0013-en	How does underrepresentation in reference databases harm underrepresented populations?	It increases uncertain findings, weakens polygenic scores and can delay diagnosis.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending
IMF-069-03-0014-en	Why must a genetic diagnosis not lead to diagnostic overshadowing?	Ordinary disease still occurs, and not every new symptom belongs to the syndrome, so each new symptom still needs its own assessment.	Integrated Medical Foundations; chapter 69, TTS module 3; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 7c4dd71231dae8015f76871009a7d35d723d9a6447f8b13784827e3c46bbdc0f; editorial review pending	imf lang::en chapter::069 module::069-03 review::pending