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IMF-037-02-0001-en	Why can a report of "susceptible" fail to predict cure?	A prescription only succeeds if enough free drug reaches the infected site, so susceptibility cannot compensate for an undrained abscess, obstructed kidney, infected prosthesis, or dose that never reaches the compartment.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0002-en	How can beta-lactam target attainment be improved without raising the total daily dose?	Efficacy relates to the fraction of the interval with unbound concentration above the minimum inhibitory concentration, so shortening the interval or extending the infusion lengthens that time.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0003-en	Why do aminoglycosides suit large separated doses in suitable patients?	Their killing relies substantially on a high peak relative to the inhibitory concentration, and a post-antibiotic effect persists between doses.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0004-en	In critical illness with renal failure, why may a full loading dose still be needed?	Capillary leak and resuscitation expand the distribution volume of hydrophilic drugs, and the loading dose depends mainly on distribution, while clearance governs only maintenance dosing.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0005-en	Why does nitrofurantoin treat lower urinary infection but not pyelonephritis or sepsis?	Urine can reach very high concentrations even when tissue levels are modest, so the drug must match the infected compartment rather than the culture source.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0006-en	How should a beta-lactam reaction history separate intolerance, a remote mild rash, and dangerous reactions?	Isolated gastrointestinal upset is intolerance, not allergy; a remote mild rash differs from immediate urticaria, bronchospasm, hypotension, or severe delayed syndromes, and severe immune reactions are not challenged casually.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0007-en	Why does a rapid molecular resistance marker not replace phenotypic susceptibility testing?	It gives rapid warning but does not describe every expressed mechanism, so phenotypic susceptibility and clinical context remain necessary.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0008-en	Why are patients on aminoglycosides asked to report tinnitus, hearing change, or imbalance?	These can signal toxicity before serum creatinine rises.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0009-en	Why do tuberculosis, human immunodeficiency virus, and selected prosthetic infections justify combination therapy after microbiology is known?	Population heterogeneity, protected compartments, or validated synergy make combinations beneficial, unlike routine double Gram-negative coverage after susceptibility is known.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0010-en	How do adherence interruptions select human immunodeficiency virus resistance?	Drugs decay at different rates, so only part of the regimen remains active, which selects resistance.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0011-en	Why is Candida in blood treated systemically while respiratory Candida usually is not?	Respiratory Candida usually represents colonisation, so treating it adds toxicity without benefit, whereas bloodstream Candida needs therapy, clearance cultures, and source review.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0012-en	Why must severe malaria be treated urgently with parenteral therapy?	Parasite burden, sequestration, haemolysis, acidosis, brain injury, and organ failure can advance quickly.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0013-en	Why should treatment failure prompt structured review rather than reflexive broadening?	Failure may reflect a non-infectious syndrome, wrong sampling, missed doses, or undrained pus or foreign material, and broader therapy adds toxicity while delaying the needed procedure.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending
IMF-037-02-0014-en	When is conversion from intravenous to oral therapy appropriate, and why is intravenous access not inherently stronger?	Convert when a bioavailable active drug reaches the site and the patient can absorb it, because efficacy depends on exposure at the site rather than on route.	Integrated Medical Foundations; chapter 37, TTS module 2; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 2e8ac568fe5450e70521bf2251441a0796b01559e624b2b97822e74e15d5342e; editorial review pending	imf lang::en chapter::037 module::037-02 review::pending