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IMF-004-01-0001-en	What do innate pattern-recognition receptors recognise?	Recurring microbial structures and signals associated with damaged cells.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0002-en	What vascular change mainly produces redness and warmth in acute inflammation?	Increased local blood flow.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0003-en	How does increased microvascular permeability cause inflammatory swelling?	Protein-rich fluid leaves vessels and accumulates in tissue.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0004-en	Which adhesion-molecule family supports leukocyte rolling?	Selectins.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0005-en	Which leukocyte molecules mediate firm adhesion after chemokine activation?	Integrins binding endothelial adhesion molecules.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0006-en	What is opsonisation?	Coating a target with molecules such as antibody or complement to improve phagocyte recognition and uptake.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0007-en	Which T-cell population recognises peptides presented by MHC class I?	CD8-positive T cells.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0008-en	Which T-cell population recognises peptides presented by MHC class II?	CD4-positive T cells.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0009-en	What is the principal immune role of regulatory T cells?	To restrain immune activation and support tolerance.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0010-en	Which differentiated B-cell form secretes antibodies?	The plasma cell.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0011-en	Which immunoglobulin class crosses the placenta?	IgG.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0012-en	Which immunoglobulin class is prominent in mucosal protection and secretions?	IgA.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0013-en	Which immunoglobulin class binds mast cells in immediate allergic responses?	IgE.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0014-en	Why does a positive autoantibody result not establish autoimmune disease on its own?	Its meaning depends on pre-test probability, titre and pattern, organ findings, and alternative explanations.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0015-en	Which organ produces C-reactive protein during the acute-phase response?	The liver.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0016-en	Does absence of fever exclude sepsis?	No. Sepsis can occur with normal or low temperature; it involves life-threatening organ dysfunction from a dysregulated response to infection.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0017-en	Why can anti-inflammatory treatment reduce symptoms without eliminating an infectious cause?	It modifies the host response rather than necessarily killing or removing the pathogen.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0018-en	What does haemostasis provide for subsequent wound repair beyond limiting bleeding?	A provisional matrix on which repair can proceed.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0019-en	Which wound-healing cells contract the wound?	Myofibroblasts.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0020-en	Why does destruction of the tissue scaffold favour scar formation over regeneration?	Regenerating specialised cells need a suitable structural framework; loss of that framework favours matrix-based repair.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0021-en	Does a remodelled scar usually regain the full tensile strength of uninjured tissue?	No. Strength increases during remodelling but usually remains below that of uninjured tissue.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0022-en	How can chronic organ fibrosis reduce physiological reserve?	Extracellular matrix replaces functional tissue and distorts organ architecture.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0023-en	What does source control address that antimicrobial exposure alone may not?	A persistent infectious focus, such as an undrained collection, infected device, or obstructed drainage pathway.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending
IMF-004-01-0024-en	Why is the site of infection important when selecting an antimicrobial?	The drug must reach effective exposure at that site, not merely show activity against the organism in principle.	Integrated Medical Foundations; chapter 4, TTS module 1; https://theisegoria.github.io/medical-textbook/integrated-medical-foundations-expanded-english.md; module SHA256 at export: 57c969e97082ad8262098cf49a3e7d378185d2c74f9ba825dd1d773a5cda319b; editorial review pending	imf lang::en chapter::004 module::004-01 review::pending